Imaging Drug Effects on Tumors

Yvonne Carts-Powell

Holographic tissue dynamics spectroscopy allows researchers to look at motion inside living tissue.

Scatterings imageDavid Nolte with spectrograms created using holographic tissue dynamics spectroscopy. The spectrograms show how cells react to drugs.

Holographic tissue dynamics spectroscopy—a method developed by Purdue researcher David Nolte with colleagues at Purdue—allows researchers to look at motion inside living tissue. It could provide a way to detect the effects of new drugs on cancerous tumors. At the recent LabAutomation Conference in Palm Springs, Calif., U.S.A., Nolte says, "It generated a lot of excitement because it is a new form of high-content screening  that works without labels that could be valuable in drug discovery." (See "Motility Contrast Imaging in Three-Dimensional Tissue-Based Drug Screening," by D. Nolte et al., LabAutomation2011.)

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