Microscopy without Lenses

Yvonne Carts-Powell

A new holographic microscope is inexpensive, compact and lightweight, and can be used for both transmission and reflection imaging with resolutions down to 2 µm.

Scatterings image(Top, left) Reconstructed amplitude reflection image from lensless microscope. (Top, right) For comparison, conventional reflection mode microscope image of same specimen made using 4X objective lens (NA: 0.1). (Bottom, left) Image of different region of interest from lensless microscope. (Bottom, right) Conventional image of same specimen.

A new holographic microscope is inexpensive, compact and lightweight, and can be used for both transmission and reflection imaging with resolutions down to 2 µm. The device—about the size of a banana—could make a significant difference to health care. It is described by Myungjun Lee, Oguzhan Yaglidere and Aydogan Ozcan from University of California, Los Angeles (U.S.A.), in Biomedical Optics Express (2, 2721).

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